I investigate genetic uniqueness. My main research area is genetic abnormalities in preimplantation embryos and how they relate to fertility and infertility. I investigate the mechanisms that produce chromosomal abnormalities in human gametes and embryos as well as the development of laboratory techniques that would allow the study of such mechanisms. I lead the Genetics of infertility project looking at whole human genomes in collaboration with the amazing Genomics England database.
My research also focuses on the genetics of antibiotic resistance of Klebsiela P. and I am currently leading the PHAROS project in collaboration with University Hospital Dorset.
Publications
Journal articles
Fordham, S.M.E., Barrow, M., Mantzouratou, A. and Sheridan, E., 2024. Genomic analyses of an Escherichia coli and Klebsiella pneumoniae urinary tract co-infection using long-read nanopore sequencing. MicrobiologyOpen, 13 (1).
Vöhringer, H.S., Sanderson, T., Sinnott, M., De Maio, N., Nguyen, T., Goater, R., Schwach, F., Harrison, I., Hellewell, J., Ariani, C.V., Gonçalves, S., Jackson, D.K., Johnston, I., Jung, A.W., Saint, C., Sillitoe, J., Suciu, M., Goldman, N., Panovska-Griffiths, J., Abnizova, I., Aigrain, L., Alderton, A., Ali, M., Allen, L., Amato, R., Anderson, R., Ariani, C., Austin-Guest, S., Bala, S., Barrett, J., Bassett, A., Battleday, K., Beal, J., Beale, M., Beaver, C., Bellany, S., Bellerby, T., Bellis, K., Berger, D., Berriman, M., Betteridge, E., Bevan, P., Binley, S., Bishop, J., Blackburn, K., Bonfield, J., Boughton, N., Bowker, S., Brendler-Spaeth, T., Bronner, I., Brooklyn, T., Buddenborg, S.K., Bush, R., Caetano, C., Cagan, A., Carter, N., Cartwright, J., Monteiro, T.C., Chapman, L., Chillingworth, T.J., Clapham, P., Clark, R., Clarke, A., Clarke, C., Cole, D., Cook, E., Coppola, M., Cornell, L., Cornwell, C., Corton, C., Crackett, A., Cranage, A., Craven, H., Craw, S., Crawford, M., Cutts, T., Dabrowska, M., Davies, M., Davies, R., Dawson, J., Day, C., Densem, A., Dibling, T., Dockree, C., Dodd, D., Dogga, S., Dorman, M., Dougan, G., Dougherty, M., Dove, A., Drummond, L., Drury, E., Dudek, M., Durham, J., Durrant, L., Easthope, E., Eckert, S., Ellis, P., Farr, B. and Fenton, M., 2021. Genomic reconstruction of the SARS-CoV-2 epidemic in England. Nature, 600 (7889), 506-511.
Wilkinson, S.A.J., Sparks, N., Kele, B., Peacock, T.P., Robson, S.C., Connor, T.R., Loman, N.J., Golubchik, T., Martinez Nunez, R.T., Bonsall, D., Rambaut, A., Snell, L.B., Livett, R., Ludden, C., Corden, S., Nastouli, E., Nebbia, G., Johnston, I., Lythgoe, K., Estee Torok, M., Goodfellow, I.G., Prieto, J.A., Saeed, K., Jackson, D.K., Houlihan, C., Frampton, D., Hamilton, W.L., Witney, A.A., Bucca, G., Pope, C.F., Moore, C., Thomson, E.C., Harrison, E.M., Smith, C.P., Rogan, F., Beckwith, S.M., Murray, A., Singleton, D., Eastick, K., Sheridan, L.A., Randell, P., Jackson, L.M., Ariani, C.V., Gonçalves, S., Fairley, D.J., Loose, M.W., Watkins, J., Moses, S., Nicholls, S., Bull, M., Amato, R., Smith, D.L., Aanensen, D.M., Barrett, J.C., Aggarwal, D., Shepherd, J.G., Curran, M.D., Parmar, S., Parker, M.D., Williams, C., Glaysher, S., Underwood, A.P., Bashton, M., Pacchiarini, N., Loveson, K.F., Byott, M., Carabelli, A.M., Templeton, K.E., de Silva, T.I., Wang, D., Langford, C.F., Sillitoe, J., Gunson, R.N., Cottrell, S., O'Grady, J., Kwiatkowski, D., Lillie, P.J., Cortes, N., Moore, N., Thomas, C., Burns, P.J., Mahungu, T.W., Liggett, S., Beckett, A.H., Holden, M.T.G., Levett, L.J., Osman, H., Hassan-Ibrahim, M.O., Simpson, D.A., Chand, M., Gupta, R.K., Darby, A.C., Paterson, S., Pybus, O.G., Volz, E.M., de Angelis, D., Robertson, D.L., Page, A.J., Martincorena, I. and Aigrain, L., 2022. Recurrent SARS-CoV-2 mutations in immunodeficient patients. Virus Evolution, 8 (2).
Cotton, S., McHugh, M.P., Dewar, R., Haas, J.G., Templeton, K., Robson, S.C., Connor, T.R., Loman, N.J., Golubchik, T., Martinez Nunez, R.T., Bonsall, D., Rambaut, A., Snell, L.B., Livett, R., Ludden, C., Corden, S., Nastouli, E., Nebbia, G., Johnston, I., Prieto, J.A., Saeed, K., Jackson, D.K., Houlihan, C., Frampton, D., Hamilton, W.L., Witney, A.A., Bucca, G., Pope, C.F., Moore, C., Thomson, E.C., Cutino-Moguel, T., Harrison, E.M., Smith, C.P., Rogan, F., Beckwith, S.M., Murray, A., Singleton, D., Eastick, K., Sheridan, L.A., Randell, P., Jackson, L.M., Ariani, C.V., Gonçalves, S., Fairley, D.J., Loose, M.W., Watkins, J., Moses, S., Nicholls, S., Bull, M., Amato, R., Smith, D.L., Aanensen, D.M., Barrett, J.C., Kele, B., Aggarwal, D., Shepherd, J.G., Curran, M.D., Parmar, S., Parker, M.D., Williams, C., Glaysher, S., Underwood, A.P., Bashton, M., Pacchiarini, N., Loveson, K.F., Byott, M., Carabelli, A.M., Peacock, S.J., de Silva, T.I., Wang, D., Langford, C.F., Sillitoe, J., Gunson, R.N., Cottrell, S., O'Grady, J., Kwiatkowski, D., Lillie, P.J., Cortes, N., Moore, N., Thomas, C., Burns, P.J., Mahungu, T.W., Liggett, S., Beckett, A.H., Holden, M.T., Levett, L.J., Osman, H., Hassan-Ibrahim, M.O., Simpson, D.A., Chand, M., Gupta, R.K., Darby, A.C., Paterson, S., Pybus, O.G., Volz, E.M., de Angelis, D., Robertson, D.L., Page, A.J. and Martincorena, I., 2023. Investigation of hospital discharge cases and SARS-CoV-2 introduction into Lothian care homes. Journal of Hospital Infection, 135, 28-36.
Willett, B.J., Grove, J., MacLean, O.A., Wilkie, C., De Lorenzo, G., Furnon, W., Cantoni, D., Scott, S., Logan, N., Ashraf, S., Manali, M., Szemiel, A., Cowton, V., Vink, E., Harvey, W.T., Davis, C., Asamaphan, P., Smollett, K., Tong, L., Orton, R.J., Hughes, J., Holland, P., Silva, V., Pascall, D.J., Puxty, K., da Silva Filipe, A., Yebra, G., Shaaban, S., Holden, M.T.G., Pinto, R.M., Gunson, R., Templeton, K., Murcia, P.R., Patel, A.H., Klenerman, P., Dunachie, S., Barnes, E., Brown, A., Adele, S., Kronsteiner, B., Murray, S.M., Abraham, P., Deeks, A., Ansari, M.A., de Silva, T., Turtle, L., Moore, S., Austin, J., Richter, A., Duncan, C., Payne, R., Ash, A., Koshy, C., Kele, B., Cutino-Moguel, T., Fairley, D.J., McKenna, J.P., Curran, T., Adams, H., Fraser, C., Bonsall, D., Fryer, H., Lythgoe, K., Thomson, L., Golubchik, T., Murray, A., Singleton, D., Beckwith, S.M., Mantzouratou, A., Barrow, M., Buchan, S.L., Reynolds, N., Warne, B., Maksimovic, J., Spellman, K., McCluggage, K., John, M., Beer, R., Afifi, S., Morgan, S., Mack, A., Marchbank, A., Price, A., Morriss, A., Bresner, C., Kitchen, C., Merrick, I., Southgate, J., Guest, M., Jones, O., Munn, R., Connor, T.R., Whalley, T., Workman, T., Fuller, W., Patel, A., Patel, B., Nebbia, G. and Edgeworth, J., 2022. Publisher Correction: SARS-CoV-2 Omicron is an immune escape variant with an altered cell entry pathway (Nature Microbiology, (2022), 7, 8, (1161-1179), 10.1038/s41564-022-01143-7). Nature Microbiology, 7 (10), 1709.
Chapters
Fragkouli, E., Alfarawati, S. and Mantzouratou, A., 2021. Individualised genetic testing: who benefits? Individualised IVF. Cambridge University Press.
Conferences
Mantzouratou, A., Xanthopoulou, L., Mania, A., Serhal, P., Delhanty, J. and SenGupta, S., 2020. Whole genome insights into male infertility. In:. I372-I373.
Xanthopoulou, L., Ghevaria, H., Mantzouratou, A., Serhal, P., Doshi, A. and Delhanty, J.D., 2010. Fragile sites and chromosome breakage in embryos from carriers of structural chromosomal abnormalities determined by preimplantation genetic diagnosis. In:. I325-I326.
Xanthopoulou, L., Mantzouratou, A., Mania, A., Ghevaria, H., Ghebo, C., Serhal, P. and Delhanty, J.D.A., 2011. When is old too old for preimplantation genetic diagnosis for reciprocal translocations? In:. I106-I107.
Mantzouratou, A., Mania, A., Xanthopolou, L., Tashkandi, S., Doshi, A., Laver, S., Serhal, P., Ranieri, D.M., Harper, J.C. and Delhanty, J.D.A., 2007. Evidence for variable aneuploidy mechanisms in embryos from couples with distinct indications for preimplantaion genetic screening (PGS). In:. 231-231.
Delhanty, J.D.A., Fragouli, E., Mantzouratou, A., Wells, D., Serhal, P. and Faed, M.J.W., 2007. Comprehensive analysis of human oocytes and 1st polar bodies by comparative genomic hybridisation (CGH). In:. 146-146.
Grants
Grants
- Genomic and proteomic surveillance of the ESKAPE pathogen Klebsiella pneumoniae using third-generation sequencing and matrix-assisted laser desorption ionization analyses.(PHAROS project). (Pfizer, 16 January 2022). Awarded
Outreach & engagement
External responsibilities
- University College London, Visiting Lecturer (2018)
- UCL, Postgraduate Supervisor for Project Development (2018)
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